The drug lisdexamfetamine is a prodrug of dextroamphetamine. As such, Vyvanse must be metabolized into dextroamphetamine for it to enact effects. Vyvanse is broken down by red blood cells and excreted through urine.
Like Adderall or methamphetamine , Vyvanse works by increasing activity in the central nervous system CNS. This action can make the individual feel more alert, attentive, and energetic. How long the effects of Vyvanse persist largely depends on the size of the dose that is used. Vyvanse, as a prodrug, must be broken down by the body before it will start to work. Once metabolized, the effects can last up to 12 hours.
The half-life of Vyvanse is based on the active ingredient lisdexamfetamine, which, as noted, has a half-life of less than an hour. It is eventually converted to dextroamphetamine, which has a much longer half-life of around 12 hours. Vyvanse can be administered in several different doses: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, or 70 mg.
How long Vyvanse can be identified on a drug screen depends on the method of testing. Conventional drug testing methods include urine, saliva, blood, and hair follicle screenings. Urine — Vyvanse can be found in a urine test for up to three days after the last use. Saliva — Saliva tests are often used because drug levels are usually similar or higher than those detected in blood, and they are much less invasive.
Vyvanse will test positive on a saliva drug screen for up to 48 hours after the last use. Blood — How long Vyvanse can be identified in the blood depends greatly on its half-life, which is relatively short. Vyvanse will only be detectable on a blood test for about 8 hours following use. Hair — A hair follicle test is sometimes used to detect the presence of drugs for much longer than which other methods are capable.
Lisdexamfetamine dimesylate has a typical plasma elimination half-life of less than an hour on average. It is quickly absorbed from the gastrointestinal tract after oral administration, and as mentioned earlier, is then converted into Dextroamphetamine, a drug with a plasma elimination half-life of about 12 hours.
This data is based on two placebo-controlled classroom studies conducted in ADHD children of ages 6 to 12 years. Half-life is one of those medical terms many people use but few understand, often thought to be how long half of the medicine remains in the system as a whole. Half-life actually refers to how long it takes for half the drug to be eliminated from the plasma of the blood. So, when speaking about Vyvanse half-life, what is specifically being referenced is how long it takes for the blood plasma levels of the drug to drop to 50 percent.
Higher concentrations can remain in other body elements for much longer. Going back to the drug of focus, the Vyvanse half-life is short, averaging on less than an hour. When the primary ingredient metabolizes, it turns into Dextroamphetamine and L-Lysine.
Dextroamphetamine has a longer half-life than Lisdexamfetamine dimesylate, coming in at around 12 hours. So, how long does Vyvanse last? The first study recorded statistical significance until the 12th hour was effective from the 2nd to 12th hour , whereas the second study found statistically significant effects until the 13th hour was effective from hours 1.
Considering the alternatives to Vyvanse , it is quite long-lasting. However, not everyone should expect the same time span. How long the drug lasts will vary from person to person, and individual factors such as gender, age, the existence of other health conditions, and the dosage taken should all be considered.
Anyone who is worried about passing a drug test for Lisdexamfetamine dimesylate is likely misusing the medication and in need of help, and not taking it for the treatment of actual health conditions like ADHD or BED.
Now, one may be wondering — how long does Vyvanse stay in your system? Again, as with other drugs or substances, it would vary depending on individual factors, the dosage one takes, and how long they have been taking it for. While the Vyvanse half-life may sound like good news, it is a bit misleading. The medication itself may be eradicated from the system in six hours or less, but the metabolites will remain. In general, it takes 5 half-lives before a single dose drug is eliminated from the body.
As has been already mentioned, it is converted into D-amphetamine after absorption from the gastrointestinal tract. And with the said drug having a significantly longer half-life of about 12 hours , it will stay in the system for around 60 hours following the last dose.
Lisdexamfetamine dimesylate may not always show up on a urine test. If the test is for amphetamines, it can be detected. Results are instant, allowing the tester to get their answers quickly. Blood testing for amphetamines is highly accurate. However, it is more difficult and more expensive than urine testing.
It is also less likely to catch the presence of a drug, including Vyvanse, if it is not being used frequently. With regards to how long Lisdexamfetamine dimesylate stays in the blood, its active ingredient, d-amphetamine, remains detectable for 3. This range is according to a study of pediatric patients aged years who were given a single oral dose of 30, 50, or 70mg of Vyvanse.
Hair testing for Lisdexamfetamine dimesylate, as well as other drugs, is expensive to complete, and as such is rare. However, it is where there is the greatest risk for a positive result. When talking about the majority of the body, it is mere hours or days, but when it comes to the hair, Vyvanse and other amphetamines can remain present and detectable for as long as three months.
Saliva testing is quite rare. Because these tests do not differentiate between amphetamine and racemic compounds such as Dextroamphetamine, the drug Lisdexamfetamine dimesylate is converted into, Vyvanse will almost certainly show up on a drug test as an amphetamine. Usually, they are looking for ways to make Vyvanse wear off faster.
However, not all variables that affect how long Vyvanse lasts in the system can be altered. While the half-life of Vyvanse has been determined through clinical tests, it is an average of all of those who were part of the trials. Some people eliminate the drug faster than others and vice versa.
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